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Hildebrandt, A. Pflanz, R. Behr, M. Tarp, T. Riedel, D. Schuh, R. Epithelial tissues separate body compartments with different compositions. Tight junctions (TJs) in vertebrates and septate junctions (SJs) in invertebrates control the paracellular flow of molecules between these compartments. This epithelial barrier function of TJs and SJs must be stably maintained in tissue morphogenesis during cell proliferation and cell movement. Here, we show that Bark beetle (Bark), a putative transmembrane scavenger receptor-like protein, is essential for the maturation but not the establishment of SJs in Drosophila. Embryos that lack bark establish functional SJs, but due to rudimentary septae formation during subsequent embryonic development, these become non-functional. Furthermore, cell adhesion is impaired at the lateral cell membrane and the core protein complexes of SJs are mis-localised, but appear to form otherwise normally in such embryos. We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis. Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society 2015-02-20 http://purl.org/escidoc/metadata/ves/publication-types/article Text escidoc:2111711 eterms:DOI: 10.1016/j.ydbio.2015.02.008 Developmental Biology eng http://purl.org/escidoc/metadata/ves/publication-types/article Text Hildebrandt, A. Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society Pflanz, R. Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society Behr, M. Tarp, T. Riedel, D. Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society Schuh, R. Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila. eng escidoc:2111711 eterms:DOI: 10.1016/j.ydbio.2015.02.008 2015-02-20 Developmental Biology Epithelial tissues separate body compartments with different compositions. Tight junctions (TJs) in vertebrates and septate junctions (SJs) in invertebrates control the paracellular flow of molecules between these compartments. This epithelial barrier function of TJs and SJs must be stably maintained in tissue morphogenesis during cell proliferation and cell movement. Here, we show that Bark beetle (Bark), a putative transmembrane scavenger receptor-like protein, is essential for the maturation but not the establishment of SJs in Drosophila. Embryos that lack bark establish functional SJs, but due to rudimentary septae formation during subsequent embryonic development, these become non-functional. Furthermore, cell adhesion is impaired at the lateral cell membrane and the core protein complexes of SJs are mis-localised, but appear to form otherwise normally in such embryos. We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis. Hildebrandt A. Pflanz R. Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society escidoc:578590 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15636 Behr M. Tarp T. Riedel D. Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society escidoc:578615 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15710 Schuh R. Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society escidoc:578591 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15806 Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila. eng 10.1016/j.ydbio.2015.02.008 2015-02-20 http://purl.org/eprint/status/PeerReviewed Developmental Biology (in press) Epithelial tissues separate body compartments with different compositions. Tight junctions (TJs) in vertebrates and septate junctions (SJs) in invertebrates control the paracellular flow of molecules between these compartments. This epithelial barrier function of TJs and SJs must be stably maintained in tissue morphogenesis during cell proliferation and cell movement. Here, we show that Bark beetle (Bark), a putative transmembrane scavenger receptor-like protein, is essential for the maturation but not the establishment of SJs in Drosophila. Embryos that lack bark establish functional SJs, but due to rudimentary septae formation during subsequent embryonic development, these become non-functional. Furthermore, cell adhesion is impaired at the lateral cell membrane and the core protein complexes of SJs are mis-localised, but appear to form otherwise normally in such embryos. We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis. Epithelial morphogenesis; Septate junction; Tracheal system Hildebrandt A. Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society escidoc:578591 http://pubman.mpdl.mpg.de/cone/persons/resource/persons61115 Pflanz R. Department of Molecular Developmental Biology, MPI for biophysical chemistry, Max Planck Society escidoc:578590 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15636 Behr M. Tarp T. Riedel D. Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society escidoc:578615 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15710 Schuh R. Research Group of Molecular Organogenesis, MPI for biophysical chemistry, Max Planck Society escidoc:578591 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15806 Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila. eng 10.1016/j.ydbio.2015.02.008 2015-02-20 http://purl.org/eprint/status/PeerReviewed Developmental Biology (in press) Epithelial tissues separate body compartments with different compositions. Tight junctions (TJs) in vertebrates and septate junctions (SJs) in invertebrates control the paracellular flow of molecules between these compartments. This epithelial barrier function of TJs and SJs must be stably maintained in tissue morphogenesis during cell proliferation and cell movement. Here, we show that Bark beetle (Bark), a putative transmembrane scavenger receptor-like protein, is essential for the maturation but not the establishment of SJs in Drosophila. Embryos that lack bark establish functional SJs, but due to rudimentary septae formation during subsequent embryonic development, these become non-functional. Furthermore, cell adhesion is impaired at the lateral cell membrane and the core protein complexes of SJs are mis-localised, but appear to form otherwise normally in such embryos. We propose a model in which Bark acts as a scaffold protein that mediates cell adhesion and mounting of SJ core complexes during cell rearrangement in tissue morphogenesis. 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