ingest fedoraAdmin 2015-03-12T13:00:07.790Z eSciDoc object created addDatastream version-history fedoraAdmin 2015-03-12T13:00:07.848Z created modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:00:07.886Z modifyObject fedoraAdmin 2015-03-12T13:02:25.534Z touched modifyObject fedoraAdmin 2015-03-12T13:02:26.199Z touched modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:02:26.232Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:02:26.262Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:02:26.293Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:02:54.940Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:02:54.970Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:02:55.003Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:00.672Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:03:00.710Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:00.749Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:01.744Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:03:01.774Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:01.813Z modifyObject fedoraAdmin 2015-03-12T13:03:02.316Z touched modifyObject fedoraAdmin 2015-03-12T13:03:02.539Z touched modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:02.595Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:03:02.625Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:02.662Z modifyObject fedoraAdmin 2015-03-12T13:03:02.860Z touched modifyObject fedoraAdmin 2015-03-12T13:03:03.053Z touched modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:03.108Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:03:03.141Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:03.178Z modifyObject fedoraAdmin 2015-03-12T13:03:03.378Z touched modifyObject fedoraAdmin 2015-03-12T13:03:03.569Z touched modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:03.629Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:03:03.663Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:03.704Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:04.329Z modifyDatastreamByValue version-history fedoraAdmin 2015-03-12T13:03:04.368Z modifyDatastreamByValue RELS-EXT fedoraAdmin 2015-03-12T13:03:04.411Z A digital atlas of ion channel expression patterns in the two-week-old rat brain. Shcherbatyy, V. Carson, J. Yaylaoglu, M. Jäckle, K. Grabbe, F. Brockmeyer, M. Yavuz, H. Eichele, G. The approximately 350 ion channels encoded by the mammalian genome are a main pillar of the nervous system. We have determined the expression pattern of 320 channels in the two-week-old (P14) rat brain by means of non-radioactive robotic in situ hybridization. Optimized methods were developed and implemented to generate stringently coronal brain sections. The use of standardized methods permits a direct comparison of expression patterns across the entire ion channel expression pattern data set and facilitates recognizing ion channel co-expression. All expression data are made publically available at the Genepaint.org database. Inwardly rectifying potassium channels (Kir, encoded by the Kcnj genes) regulate a broad spectrum of physiological processes. Kcnj channel expression patterns generated in the present study were fitted with a deformable subdivision mesh atlas produced for the P14 rat brain. This co-registration, when combined with numerical quantification of expression strengths, allowed for semi-quantitative automated annotation of expression patterns as well as comparisons among and between Kcnj subfamilies. The expression patterns of Kcnj channel were also cross validated against previously published expression patterns of Kcnj channel genes. Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society 2015-01-01 http://purl.org/escidoc/metadata/ves/publication-types/article Text 111-125 escidoc:2111495 eterms:DOI: 10.1007/s12021-014-9247-0 Neuroinformatics 13 1 eng Shcherbatyy V. Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society escidoc:persistent34 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15828 Carson J. Yaylaoglu M. Jäckle K. Grabbe F. Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society escidoc:persistent34 http://pubman.mpdl.mpg.de/cone/persons/resource/persons32700 Brockmeyer M. Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society escidoc:persistent34 http://pubman.mpdl.mpg.de/cone/persons/resource/persons31788 Yavuz H. Department of Neurobiology, MPI for Biophysical Chemistry, Max Planck Society escidoc:578595 http://pubman.mpdl.mpg.de/cone/persons/resource/persons132892 Eichele G. Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society escidoc:persistent34 http://pubman.mpdl.mpg.de/cone/persons/resource/persons15030 A digital atlas of ion channel expression patterns in the two-week-old rat brain. eng 10.1007/s12021-014-9247-0 2015-01-01 http://purl.org/eprint/status/PeerReviewed Neuroinformatics 13 1 111 125 The approximately 350 ion channels encoded by the mammalian genome are a main pillar of the nervous system. We have determined the expression pattern of 320 channels in the two-week-old (P14) rat brain by means of non-radioactive robotic in situ hybridization. Optimized methods were developed and implemented to generate stringently coronal brain sections. The use of standardized methods permits a direct comparison of expression patterns across the entire ion channel expression pattern data set and facilitates recognizing ion channel co-expression. All expression data are made publically available at the Genepaint.org database. Inwardly rectifying potassium channels (Kir, encoded by the Kcnj genes) regulate a broad spectrum of physiological processes. Kcnj channel expression patterns generated in the present study were fitted with a deformable subdivision mesh atlas produced for the P14 rat brain. This co-registration, when combined with numerical quantification of expression strengths, allowed for semi-quantitative automated annotation of expression patterns as well as comparisons among and between Kcnj subfamilies. The expression patterns of Kcnj channel were also cross validated against previously published expression patterns of Kcnj channel genes. Ion channels; Gene expression analysis; In situ hybridization; Genepaint.org database; Rat brain; Digital atlas; Subdivision mesh 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry pending Object created. ct Andrea Piepkorn Andrea Piepkorn Object created. pending ---1 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry pending Object created. ct Andrea Piepkorn Andrea Piepkorn Object created. pending 2015-03-12T13:00:07.800Z 1 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry pending Object created. ct Andrea Piepkorn Andrea Piepkorn ItemHandler.update() pending 2015-03-12T13:00:07.800Z 2 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry pending Object created. ct Andrea Piepkorn Andrea Piepkorn ItemHandler.update() pending 2015-03-12T13:02:26.232Z 2 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:02:26.232Z 2 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:02:54.940Z 2 hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:02:54.940Z 2 hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:00.672Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:00.672Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:01.744Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:01.744Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:02.595Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:02.595Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:03.108Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:03.108Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry submitted ct Andrea Piepkorn Andrea Piepkorn submitted 2015-03-12T13:03:03.629Z 2 hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry released ct Andrea Piepkorn Andrea Piepkorn released 2015-03-12T13:03:03.629Z 2 2 --- hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C94-B hdl:11858/00-001M-0000-0025-6C93-D 1.3.10-SNAPSHOT Publications of the MPI for Biophysical Chemistry released ct Andrea Piepkorn Andrea Piepkorn released 2015-03-12T13:03:04.329Z 2 2 2015-03-12T13:03:04.329Z hdl:11858/00-001M-0000-0025-6C94-B 2 2015-03-12T13:03:04.329Z released URL /ir/item/escidoc:2111495/resources/version-history#v2e1426165384166 released 2015-03-12T13:03:04.329Z escidoc-internal escidoc:604559 escidoc-internal escidoc:2111495 URL /ir/item/escidoc:2111495/resources/version-history#v2e1426165381531 assignVersionPid 2015-03-12T13:03:00.749Z versionPid assigned escidoc-internal escidoc:604559 escidoc-internal escidoc:2111495 URL /ir/item/escidoc:2111495/resources/version-history#v2e1426165380505 assignObjectPid 2015-03-12T13:02:55.003Z objectPid assigned escidoc-internal escidoc:604559 escidoc-internal escidoc:2111495 URL /ir/item/escidoc:2111495/resources/version-history#v2e1426165374757 submitted 2015-03-12T13:02:54.940Z escidoc-internal escidoc:604559 escidoc-internal escidoc:2111495 URL /ir/item/escidoc:2111495/resources/version-history#v2e1426165346180 update 2015-03-12T13:02:26.232Z ItemHandler.update() escidoc-internal escidoc:604559 escidoc-internal escidoc:2111495 1 2015-03-12T13:00:07.800Z pending Object created. 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